Apparent exchange rate imaging: On its applicability and the connection to the real exchange rate

نویسندگان

چکیده

Purpose Water exchange between the intracellular and extracellular space can be measured using apparent rate (AXR) imaging. The aim of this study was to investigate relationship AXR geometry diffusion restrictions, membrane permeability, real rate, as well explore applicability for typical human measurement settings. Methods measurements underlying rates were simulated Monte Carlo method with different geometries, size distributions, packing densities, a broad range permeabilities. Furthermore, influence SNR sequence parameters analyzed. Results estimated values correspond show expected proportionality except fast (ie, ) small densities. Moreover, it found that duration filter gradient must shorter than . In cell permeability depends on average surface-to-volume ratio, density. Finally, reliably determined in presence orientation dispersion axon-like structures sufficient sampling 30 directions). Conclusion Currently used experimental settings vivo are suited determining AXR, exception single-voxel analysis, due limited SNR. detection changes diseased tissue is nonetheless challenging because dependence further factors, such density geometry, which cannot disentangled without knowledge structure.

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ژورنال

عنوان ژورنال: Magnetic Resonance in Medicine

سال: 2021

ISSN: ['0740-3194', '1522-2594']

DOI: https://doi.org/10.1002/mrm.28714